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Istradefylline forty mg/working day increased peak ranges and AUC of CYP3A4 substrates in clinical trials. This outcome was not noticed with istradefylline 20 mg/day. Think about dose reduction of sensitive CYP3A4 substrates.modafinil will reduce the level or impact of fruquintinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or